Aminooxy-PEG8-acid
Aminooxy-PEG8-acid Basic information
- Product Name:
- Aminooxy-PEG8-acid
- Synonyms:
-
- Propanoic acid, 3-[[23-(aminooxy)-3,6,9,12,15,18,21-heptaoxatricos-1-yl]oxy]-
- CAS:
- 2055269-60-6
- MF:
- C19H39NO11
- MW:
- 457.51
- Mol File:
- 2055269-60-6.mol
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Aminooxy-PEG8-acid Chemical Properties
- Boiling point:
- 575.8±50.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
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Aminooxy-PEG8-acid Usage And Synthesis
Biological Activity
Aminooxy-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Aminooxy-PEG8-acidSupplier
Amatek Scientific Co. Ltd.
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Xian confluore Biological Technology Co., Ltd.
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