Aminooxy-PEG8-acid Chemical Properties

Boiling point:

575.8±50.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

Aminooxy-PEG8-acid Usage And Synthesis

Biological Activity

Aminooxy-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Aminooxy-PEG8-acid(2055269-60-6)Related Product Information

• Aminooxy-PEG8-t-butyl ester
• Aminooxy-PEG2-NH-Boc