Basic information Safety Supplier Related

sulfaguanole

Basic information Safety Supplier Related

sulfaguanole Basic information

Product Name:
sulfaguanole
Synonyms:
  • sulfaguanole
  • Sulfaguanol
  • 4-Amino-N-[[(4,5-dimethyl-2-oxazolyl)amino](imino)methyl]benzenesulfonamide
  • Benzenesulfonamide, 4-amino-N-[[(4,5-dimethyl-2-oxazolyl)amino]iminomethyl]-
CAS:
27031-08-9
MF:
C12H15N5O3S
MW:
309.34
EINECS:
248-175-4
Mol File:
27031-08-9.mol
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sulfaguanole Chemical Properties

Melting point:
233-236°; mp 228-230°
Boiling point:
510.0±52.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
pka
7.76(at 25℃)
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sulfaguanole Usage And Synthesis

Originator

Enterocura,Nordmark,W. Germany,1973

Definition

ChEBI: Sulfaguanole is a sulfonamide.

Manufacturing Process

23.9 grams (0.1 mol) of N1-[p-amino benzene sulfonyl]-N3-cyanoguanidine and 13.2 grams (0.15 mol) of acetoin are thoroughly stirred in a mixture of 120 cc of water and 120 cc of methanol. 25 cc of concentrated hydrochloric acid are added dropwise with stirring to this suspension at 40°C. A clear solution is obtained after 30 minutes which solution is kept at 40°C for another hour. Thereafter, the methanol is distilled off in a vacuum, the remaining solution is treated with charcoal and the pH of the filtered solution is quickly brought to 11 by addition of 10% soda lye with quick stirring.
The compound at first precipitated is redissolved at a pH of 11. The solution is treated another time with charcoal and is filtered. Thereafter, a mixture of anhydrous acetic acid and water in a proportion of 1:1 is added with stirring and cooling until a pH of 7 is reached. Thus, the reaction product separates with crystallization.
For purification, the product is recrystallized from 15 times the amount of a 9:1 mixture of acetone and water. The resulting N1-[p-amino benzene sulfonyl] -N3-(4,5-dimethyl-oxazolyl-(2)]-guanidine is obtained as colorless crystals having a MP of 233° to 236°C.

Therapeutic Function

Antibacterial

sulfaguanoleSupplier

Lanospharma Laboratories Co.,Ltd
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13440048448
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sales@lanospharma.com
Service Chemical Inc.
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888-895-6920
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sales@chemos-group.com
Shanghai New Union Textra Import & Export Co., Ltd
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+861-348-227-9455
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zhou@pharmchemical.com