2-aminopropanediamide Chemical Properties

Melting point:

180-185°C

Boiling point:

410.1±40.0 °C(Predicted)

Density 

1.399±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO (Sparingly), Methanol (Sparingly)

pka

9.87±0.70(Predicted)

form 

Solid

color 

Pale Yellow to Beige

InChI

InChI=1S/C3H7N3O2/c4-1(2(5)7)3(6)8/h1H,4H2,(H2,5,7)(H2,6,8)

InChIKey

GFQBSQXXHYLABK-UHFFFAOYSA-N

SMILES

C(N)(=O)C(N)C(N)=O

CAS DataBase Reference

62009-47-6

Safety Information

HS Code 

2924190090

2-aminopropanediamide Usage And Synthesis

Chemical Properties

Beige Solid

Uses

2-aminopropanediamide is a reagent used in the synthesis of Imidazole derivatives.

Synthesis

The general procedure for the synthesis of 2-aminomalonamide from diethyl aminomalonate is as follows: 17.5 g of diethyl 2-aminomalonate and 22 g of 50% aqueous ammonium chloride were accurately weighed, mixed, and then heated at reflux for 2 h at 100 °C. The reaction was completed by filtration. After completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was separated by filtration. The resulting solid was dried with hot air at 60 °C for 8 h. A white crystalline powder 2-aminomalonamide 10.2 g was obtained in 87% yield.

References

[1] Patent: WO2007/144686, 2007, A1. Location in patent: Page/Page column 129-130
[2] Patent: CN108250104, 2018, A. Location in patent: Paragraph 0016; 0017; 0018; 0019
[3] Patent: EP2196460, 2010, A1. Location in patent: Page/Page column 5; 6
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 78,79, 80

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