N2-methylpyridine-2,5-diamine Chemical Properties

Boiling point:

306.4±22.0 °C(Predicted)

Density 

1.179±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

7.56±0.10(Predicted)

N2-methylpyridine-2,5-diamine Usage And Synthesis

Synthesis

GENERAL METHOD: 2-chloro-5-nitropyridine (50 mmol), morpholine (100 mmol), and K2CO3 (100 mmol) were dissolved in THF (50 mL), and the reaction was stirred at 80 °C for 4 hours. Upon completion of the reaction, the mixture was concentrated to 20 mL and subsequently poured into water (100 mL) to precipitate a yellow solid precipitate. After filtration, washing with pure water and drying, the target compound 3a was obtained.Compound 3b was prepared by the same method. Compounds 3a-3b (20 mmol) were mixed with Pd/C (20%, 500 mg) in methanol and subjected to hydrogenation reaction for 12 h at room temperature. At the end of the reaction, the reaction solution was filtered and concentrated to obtain the target compounds 4a-4b.

References

[1] Chinese Chemical Letters, 2016, vol. 27, # 1, p. 1 - 6
[2] Patent: WO2005/28452, 2005, A1. Location in patent: Page/Page column 94
[3] Patent: WO2006/100588, 2006, A1. Location in patent: Page/Page column 63
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 1, p. 18 - 25
[5] Patent: US2012/258951, 2012, A1. Location in patent: Page/Page column 77

N2-methylpyridine-2,5-diamine(28020-36-2)Related Product Information

• 1-(5-Nitropyridin-2-yl)piperazine
• 5-NITRO-2-(N-PROPYLAMINO)PYRIDINE
• 4-(5-Nitropyridin-2-yl)morpholine
• 2-(2-AMINOETHYLAMINO)-5-NITROPYRIDINE
• N-ethyl-5-nitropyridin-2-amine
• N2-CYCLOPROPYL-5-NITROPYRIDIN-2-AMINE, 97
• N,N-dimethyl-5-nitropyridin-2-amine
• 2-CYCLOHEXYLAMINO-5-NITROPYRIDINE
• DNPYR-L-ISOLEUCINE MONOCYCLOHEXYL AMMONI UM
• (R)-(+)-2-(ALPHA-METHYLBENZYLAMINO)-5-NITROPYRIDINE
• DNPYR-DL-NORLEUCINE
• 5-NITRO-2-BENZYLAMINO PYRIDINE
• 5-NITRO-2-(1-PIPERIDINYL)PYRIDINE
• DNPY-DL-ALANINE
• DINITROPYRIDYL-DL-METHIONINE
• 2-(3-METHOXYPROPYLAMINO)-5-NITROPYRIDINE
• DNPY-GLYCINE
• 5-NITRO-2-ANILINO PYRIDINE