α-Amanitin
α-Amanitin Basic information
- Product Name:
- α-Amanitin
- Synonyms:
-
- α-Amanitin
- CAS:
- 11030-71-0
- MF:
- C39H53N9O14S
- MW:
- 903.95502
- Mol File:
- 11030-71-0.mol
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α-Amanitin Chemical Properties
- Melting point:
- 245 °C (decomp)
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Safety Information
- Toxicity
- A drug derived from the highly poisonous fungus Amanita phalloides (death cap). Alpha-amanitin, a cyclic octapeptide, is toxic because of its affinity for RNA polymerase II in eukaryotic cells. Since this enzyme is responsible for mRNA synthesis in the cell, the compound is a potent and selective inhibitor of mRNA synthesis. It is effective at concentrations below 1 μg/mL, and its specific action has made it useful in experimental biology. It is often used with actinomycin D to block RNA synthesis.