(2'S)-Nicotine 1-Oxide Chemical Properties

Boiling point:

347.9±30.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator, Under Inert Atmosphere

solubility 

DMF: 50 mg/mL; DMSO: 30 mg/mL; Ethanol: 50 mg/mL; PBS (pH 7.2): 1 mg/mL

form 

A crystalline solid

pka

8.79±0.40(Predicted)

Stability:

Very Hygroscopic

CAS DataBase Reference

2820-55-5

Safety Information

HS Code 

2933399990

(2'S)-Nicotine 1-Oxide Usage And Synthesis

Description

(2''S)-Nicotine-1-oxide is a metabolite of nicotine . It is formed when nicotine is metabolized in the liver by cytochrome P450 (CYP) isoform CYP2A6. (2''S)-Nicotine-1-oxide has been detected in human sperm and semen.

Chemical Properties

Light Yellow Crystals

Uses

Nicotine-1’-N-oxide is a derivative of nicotine found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1’-N-oxide has also been identified as metabolites of nicotine in animals and in man. The metabolism of nicotine i

Uses

Nicotine-1’-N-oxide is a derivative of Nicotine (N412420) found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1’-N-oxide has also been identified as metabolites of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1’-N-oxide (both diastereomers) or cotinine. The ratio of these two products has been suggested as an indicator of bladder cancer in humans.

Definition

ChEBI: A member of the class of pyridine N-oxides obtained by oxidation of the pyridine nitrogen of (S)-nicotine.

(2'S)-Nicotine 1-Oxide(2820-55-5)Related Product Information

• 3-Aminomethylpyridine-n-oxide
• 3-(1-METHYL-2-PYRROLIDINYL)PYRIDINIUM-1-OLATE
• (2'S)-Nicotine 1-Oxide
• Nicotine
• (1'RS,2'S)-Nicotine 1,1'-Di-N-Oxide