Bis(2-mercaptoethyl) sulfone Chemical Properties

Melting point:

57-58°C

Boiling point:

375.6±27.0 °C(Predicted)

Density 

1.296±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

solid

pka

pKa (aqueous soln at 25°): 7.9, 9.0

color 

Pale yellow

Stability:

Moisture Sensitive

CAS DataBase Reference

145626-87-5

Safety Information

HS Code 

2930909899

Bis(2-mercaptoethyl) sulfone Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

Bis(2-mercaptoethyl) sulfone is a useful reagent for the reduction of disulfides in aquous solutions. It is a superior substitute for DTT.

Uses

Reagent for reduction of disulfide bonds in aqueous solutions.

reaction suitability

reagent type: reductant

Purification Methods

BMS recrystallises from hexane as white fluffy crystals. Large amounts are best recrystallised from de-oxygenated H2O (charcoal). It is a good alternative reducing agent to dithiothreitol. Its IR (film) has 2995, 2657, 1306, 1248, 1124 and 729 cm-1 . The synthetic intermediate thioacetate has m 82-83o (white crystals from CCl4). The disulfide is purified by flash chromatography on SiO2 and elution with 50% EtOAc/hexane and recrystallised from hexane, and has m 137-139o. [Lamoureux & Whitesides J Org Chem 58 633 1993, Beilstein 1 IV 2455.]

Bis(2-mercaptoethyl) sulfone(145626-87-5)Related Product Information

• BIS(2-ACETYLMERCAPTOETHYL) SULFONE
• AKOS BBS-00004822
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• Bis(2-mercaptoethyl) sulfone
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