Brofaromine
Brofaromine Basic information
- Product Name:
- Brofaromine
- Synonyms:
-
- 4-(7-bromo-5-methoxybenzofuran-2-yl)piperidine
- 4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
- Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-
- CAS:
- 63638-91-5
- MF:
- C14H16BrNO2
- MW:
- 310.19
- Mol File:
- 63638-91-5.mol
Brofaromine Chemical Properties
- Boiling point:
- 404.0±45.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (805.96 mM)
- form
- Solid
- pka
- 9.99±0.10(Predicted)
- color
- Off-white to light yellow
Brofaromine Usage And Synthesis
Uses
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2?μM for MAO-A.
Biological Activity
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor, inhibits MAO-A with IC50 of 0.2 μM.
in vitro
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM.
target
IC50: 0.2 μM (MAO-A)
References
[1] Boland A, et al. Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition. Br J Pharmacol. 2002 Feb;135(3):713-20. DOI:10.1038/sj.bjp.0704519
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