Tylocrebrine
Tylocrebrine Basic information
- Product Name:
- Tylocrebrine
- Synonyms:
-
- Tylocrebrine
- [13aR,(+)]-9,11,12,13,13a,14-Hexahydro-2,3,5,6-tetramethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline
- Brn 1555044
- Dibenzo(F,H)pyrrolo(1,2-B)isoquinoline, 9,11,12,13,13A,14-hexahydro-2,3,5,6-tetramethoxy-
- Dibenzo(F,H)pyrrolo(1,2-B)isoquinoline, 9,11,12,13,13A,14-hexahydro-2,3,5,6-tetramethoxy-, (R)- (9ci)
- Lylocrebrine
- Nsc-60387
- Tylocerebrine
- CAS:
- 6879-02-3
- MF:
- C24H27NO4
- MW:
- 393.48
- Mol File:
- 6879-02-3.mol
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Tylocrebrine Chemical Properties
- Melting point:
- 220 °C
- Boiling point:
- 559.9±45.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- pka
- 7.62±0.20(Predicted)
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Tylocrebrine Usage And Synthesis
Uses
Tylocrebrine is a compound with anticancer activity. Its clinical research was interrupted due to toxicity issues. By making it into targeted nanoparticles, its inhibitory index can be improved, the killing effect on tumor cells can be enhanced and brain penetration can be reduced.
References
[1] Reformulating Tylocrebrine in Epidermal Growth Factor Receptor Targeted Polymeric Nanoparticles Improves Its Therapeutic Index DOI:10.1021/acs.molpharmaceut.5b00173