NSC360636 Chemical Properties

Melting point:

124-126 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))

Boiling point:

365.0±22.0 °C(Predicted)

Density 

1.455±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

6.67±0.50(Predicted)

NSC360636 Usage And Synthesis

Synthesis

General procedure for the synthesis of ethyl 4-nitropyrazole-3-carboxylate from ethanol and 4-nitropyrazole-3-carboxylic acid: 4-nitro-1H-pyrazole-3-carboxylic acid (2.5 g, 15.9 mmol) was dissolved in hydrochloric acid solution (38.3 mL, 1.25 M) in ethanol, followed by refluxing the mixture overnight. Upon completion of the reaction, all volatiles were removed by evaporation to afford the white solid product ethyl 4-nitropyrazole-3-carboxylate (2.9 g, 98% yield), which could be used in subsequent reactions without further purification. Results of mass spectrometry analysis: M = 186.1 (M + H)+.

References

[1] Patent: US2011/306589, 2011, A1. Location in patent: Page/Page column 45
[2] Patent: WO2011/154327, 2011, A1. Location in patent: Page/Page column 118
[3] Patent: WO2006/70198, 2006, A1. Location in patent: Page/Page column 122-123
[4] Patent: WO2006/3440, 2006, A1. Location in patent: Page/Page column 147
[5] Patent: WO2006/77414, 2006, A1. Location in patent: Page/Page column 142

NSC360636(55864-87-4)Related Product Information

• 1-ETHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 5-ETHYL-2-METHYL-4-NITRO-2 H-PYRAZOLE-3-CARBOXYLIC ACID
• NSC360636
• 1-ETHYL-3-METHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• AKOS 90441
• 1-(2,4-DIFLUOROPHENYL)-3-METHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1-METHYL-3-(2-METHYLPROPYL)-4-NITRO-1H-PYRAZOLE-5-CARBOXYLICACIDETHYLESTER
• CBI-BB ZERO/001594
• 1-(2,4-DIFLUOROPHENYL)-3-ETHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1,3-DIETHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1-ETHYL-4-NITRO-3-(2-METHYLPROPYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1-METHYL-4-NITRO-1 H-PYRAZOLE-3,5-DICARBOXYLIC ACID DIETHYL ESTER
• 1-(4-FLUOROPHENYL)-3-(2-METHYLPROPYL)-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1-(4-FLUOROPHENYL)-3-METHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1-(2,4-DIFLUOROPHENYL)-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 3-ETHYL-1-(4-FLUOROMETHYL)-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER