2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT
2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT Basic information
- Product Name:
- 2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT
- Synonyms:
-
- Guanosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, dilithium salt
- 2''-Deoxy-5''-guanosine-(tetrahydrogen triphosphate) dilithium salt
- 2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT
- DGTP-LI2
- (2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]oxolan-3-olate
- CAS:
- 95648-75-2
- MF:
- C10H17LiN5O13P3
- MW:
- 515.13
- EINECS:
- 306-016-7
- Mol File:
- 95648-75-2.mol
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2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT Chemical Properties
- storage temp.
- −20°C
MSDS
- Language:English Provider:SigmaAldrich
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2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT Usage And Synthesis
Uses
dGTP-15N5 (2'-Deoxyguanosine-5'-triphosphate-15N5) dilithium is 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6. DOI:10.1128/JB.00567-19