Isopenbutolol
Isopenbutolol Basic information
- Product Name:
- Isopenbutolol
- Synonyms:
-
- d-Penbutolol
- Isopenbutolol
- (2R)-1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)-2-propanol
- [R,(+)]-1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)-2-propanol
- Ccris 2854
- R-(+)-Isopenbutolol
- (+)-(R)-Penbutolol
- (+)-Isopenbutolol
- CAS:
- 38363-41-6
- MF:
- C18H29NO2
- MW:
- 291.43
- Mol File:
- 38363-41-6.mol
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Isopenbutolol Chemical Properties
- Boiling point:
- 438.2±40.0 °C(Predicted)
- Density
- 1.030±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.90±0.20(Predicted)
- color
- White to off-white
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Isopenbutolol Usage And Synthesis
Definition
ChEBI: (+)-Penbutolol is an aromatic ether.
Biological Activity
Isopenbutololl is a beta-adrenergic antagonist with an IC50 value of 0.74 μM. It is also an optical isomer of (-)-penbutolol, which blocks Na+ channels.
in vitro
(+)-penbutolol on the [Ca 2+ ] i -increase induced by LPC is concentration-dependent.
(+) -penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10 -6 M, 5×10 -6 M and 10 -5 M, respectively).
target
IC50: 0.74 μM (β-adrenoceptor).
IsopenbutololSupplier
Fan De(Beijing) Biotechnology Co., Ltd.
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