11-DEOXY-13,14-DIHYDRO-15-KETO-11BETA,16CHI-CYCLOPROSTAGLANDIN E2
11-DEOXY-13,14-DIHYDRO-15-KETO-11BETA,16CHI-CYCLOPROSTAGLANDIN E2 Basic information
- Product Name:
- 11-DEOXY-13,14-DIHYDRO-15-KETO-11BETA,16CHI-CYCLOPROSTAGLANDIN E2
- Synonyms:
-
- 11-DEOXY-13,14-DIHYDRO-15-KETO-11BETA,16CHI-CYCLOPROSTAGLANDIN E2
- BICYCLO PROSTAGLANDIN E2
- CGCZPIJMGKLVTQ-PAJBVNRRSA-N
- (Z)-7-[(2,5-Dioxo-4-butyloctahydro-1H-inden)-1-yl]-5-heptenoic acid
- 5-Heptenoic acid, 7-[(1R,3aS,7aS)-4-butyloctahydro-2,5-dioxo-1H-inden-1-yl]-, (5Z)-
- CAS:
- 109826-53-1
- MF:
- C20H30O4
- MW:
- 334.45
- Mol File:
- 109826-53-1.mol
11-DEOXY-13,14-DIHYDRO-15-KETO-11BETA,16CHI-CYCLOPROSTAGLANDIN E2 Chemical Properties
- Boiling point:
- 510.3±35.0 °C(Predicted)
- Density
- 1.069±0.06 g/cm3(Predicted)
- solubility
- DMF: >25 mg/ml
DMSO: >25 mg/ml
Ethanol: >30 mg/mlPBS (pH 7.2): >1.4 mg/ml - pka
- 4.75±0.10(Predicted)
11-DEOXY-13,14-DIHYDRO-15-KETO-11BETA,16CHI-CYCLOPROSTAGLANDIN E2 Usage And Synthesis
Uses
bicyclo-PGE2 (bicyclo-PGEM) is a stable decomposition product of PGE2 and 13, 14-dihydro-15-ketone PGE2[1].
Definition
ChEBI: Bicyclo-PGE2 is a prostanoid.
References
[1] Mucha I, et al. Separation of 125I-labelled prostanoid derivatives by reversed-phase high-performance liquid chromatography. J Chromatogr. 1989 Dec 8;483:419-26. DOI:10.1016/s0021-9673(01)93144-9
[2] M. HAMBERG B S. On the Metabolism of Prostaglandins E1 and E2 in Man[J]. Journal of Biological Chemistry, 1971, 246 1: 6713-6721. DOI: 10.1016/s0021-9258(19)45905-x
[3] A LEONHARDT. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis.[J]. British Journal of Dermatology, 1997, 136 3: 337-340.
[4] R C MURPHY G A F. Current approaches to estimation of eicosanoid formation in vivo.[J]. Advances in prostaglandin, thromboxane, and leukotriene research, 1994, 22: 341-348.
[5] E. GRANSTRÖM . Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability[J]. Prostaglandins, 1980, 19 6: Pages 933-957. DOI: 10.1016/0090-6980(80)90127-6