macbecin I
macbecin I Basic information
- Product Name:
- macbecin I
- Synonyms:
-
- macbecin I
- (6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin
- (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
- Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)-
- Macbecin
- CAS:
- 73341-72-7
- MF:
- C30H42N2O8
- MW:
- 558.67
- Mol File:
- 73341-72-7.mol
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macbecin I Chemical Properties
- Melting point:
- 205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Boiling point:
- 736.2±60.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 8.62±0.70(Predicted)
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macbecin I Usage And Synthesis
Uses
Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.
Biological Activity
Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ).
macbecin ISupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
EMMX Biotechnology LLC
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- 888-539-0666
- info@emmx.com
TargetMol Chemicals Inc.
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- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com
MedBioPharmaceutical Technology Inc
- Tel
- 021-69568360 18916172912
- order@med-bio.cn