nucleocidin Chemical Properties

Melting point:

>190° (dec)

Boiling point:

747.6±70.0 °C(Predicted)

Density 

2.23±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

9.15±0.70(Predicted)

Safety Information

Toxicity

LD50 i.p. in mice: ~0.2 mg/kg (Thomas)

nucleocidin Usage And Synthesis

Uses

Nucleocidin is used in studies relating to novel parasite inhibitors.

Definition

ChEBI: Nucleocidin is a nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness. It has a role as a bacterial metabolite, an antibacterial agent, a trypanocidal drug, a protein synthesis inhibitor and a nucleoside antibiotic. It is a member of adenosines, an organofluorine compound, a sulfamate ester, a member of 6-aminopurines and a diol. It is functionally related to an adenosine.

nucleocidin(24751-69-7)Related Product Information

• Sulfamic acid
• nucleocidin