neothramycin A
neothramycin A Basic information
- Product Name:
- neothramycin A
- Synonyms:
-
- neothramycin A
- (3S)-1,2,3,11aβ-Tetrahydro-3,8-dihydroxy-7-methoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
- 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 1,2,3,11a-tetrahydro-3,8-dihydroxy-7-methoxy-, (3S,11aS)-
- CAS:
- 59593-16-7
- MF:
- C13H14N2O4
- MW:
- 262.26
- Mol File:
- 59593-16-7.mol
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neothramycin A Usage And Synthesis
Description
Neothramycin A is a pyrrol[1,4]benzodiazepine antibiotic.
Uses
Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models[1].
References
[1] Takeuchi T, et al., Neothramycins A and B, new antitumor antibiotics. J Antibiot (Tokyo). 1976 Jan;29(1):93-6. DOI:10.7164/antibiotics.29.93