prothracarcin
prothracarcin Basic information
- Product Name:
- prothracarcin
- Synonyms:
-
- prothracarcin
- (2E,11R,11aS)-2-Ethylidene-11-hydroxy-1,2,3,10,11,11aβ-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
- [11aS,2E,(+)]-2-Ethylidene-1,2,3,11aβ-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one
- Antibiotic DC-62
- DC-62
- CAS:
- 81542-99-6
- MF:
- C14H14N2O
- MW:
- 226.278
- Mol File:
- 81542-99-6.mol
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prothracarcin Usage And Synthesis
Uses
Prothracarcin is an antibiotic with antitumor activity that exerts its tumor cell toxicity by covalently binding to the C-2 amino group of guanine residues in the minor groove of DNA. Prothracarcin also shows antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria such as Escherichia coli[1].
References
[1] Fotso, et al. Limazepines A? F, Pyrrolo [1, 4] benzodiazepine Antibiotics from an Indonesian Micrococcus sp. Journal of natural products 72.4 (2009): 690-695. DOI:10.1021/np800827w