3,5-Difluoro-4-pyridinecarboxaldehyde Chemical Properties

Melting point:

51-52℃

Boiling point:

169℃

Density 

1.392

Flash point:

56℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-1.60±0.28(Predicted)

Appearance

Light yellow to yellow Solid

InChI

InChI=1S/C6H3F2NO/c7-5-1-9-2-6(8)4(5)3-10/h1-3H

InChIKey

RLAOKDGTZKSUJB-UHFFFAOYSA-N

SMILES

C1=NC=C(F)C(C=O)=C1F

Safety Information

HS Code 

2933399990

3,5-Difluoro-4-pyridinecarboxaldehyde Usage And Synthesis

Uses

3,5-Difluoropyridine-4-carboxaldehyde is an aldehyde organic compound that can be used as a pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of 3,5-difluoropyridine-4-carbaldehyde from methyl formate and 3,5-difluoropyridine: Preparation of Example 10: N-[(3,5-difluoro-4-pyridinyl)methyl]-2-(trifluoromethyl)pyridine-3-carboxamide (Compound A126) Step 1: Synthesis of 3,5-difluoropyridine-4-carbaldehyde A 2M solution of LDA (47.792 mL, 95.58 mmol) was diluted with 50 mL of THF at 0°C and cooled to -78°C. Subsequently, a 100 mL THF solution of 3,5-difluoropyridine (7.886 mL, 86.89 mmol) was added dropwise, keeping the temperature lower than -70°C (the dropwise addition process was controlled to be completed within 20 min). The reaction mixture formed a yellow suspension. Stirring was continued at -78°C for 3 hours. Then, 25 mL of THF solution of methyl formate (10.8 mL, 173.79 mmol) was added and the reaction mixture was transformed into a light yellow solution and stirred at -75°C for 45 minutes. The reaction mixture was transferred by cannula to 100 mL of stirred saturated aqueous NaHCO3 solution, maintained at about 0°C. The solution was extracted with EtOAc, the organic phases were combined and washed with brine and dried with 1N HCl. The solvent was evaporated at 165 mbar, 30°C to give 36.7 g of yellow liquid crude product. The crude product was purified by fast chromatography (eluent: CH2Cl2) to give a light yellow oil (7.85 g), which was crystallized after standing. 1H-NMR (CDCl3) data: δ 10.4 (s, 1H), 8.57 (s, 2H).

References

[1] Patent: US2014/128386, 2014, A1. Location in patent: Paragraph 1410; 1411; 1412; 1413; 1414
[2] Patent: US2017/57954, 2017, A1. Location in patent: Paragraph 0630; 0631; 0632; 0633; 0634
[3] Patent: US2009/286800, 2009, A1. Location in patent: Page/Page column 107-108
[4] Patent: WO2013/64521, 2013, A1. Location in patent: Page/Page column 112
[5] Patent: US2017/217954, 2017, A1

3,5-Difluoro-4-pyridinecarboxaldehyde(870234-98-3)Related Product Information

• 2-Pyridinecarboxaldehyde,3,5-dimethyl-(9CI)
• (3,5-DIFLUOROPYRIDIN-4-YL)BORONIC ACID
• 3,5-Dichloro-4-Methoxy-pyridine
• 3,5-DIAMINOBENZONITRILE
• 3,5-DIBROMO-4-PYRIDINOL
• 3,5-Dichloro-4-hydroxypyridine
• 3,5-Dichloro-2(1H)-pyrazinone
• ETHYL 3,5-DIBROMOISONICOTINATE
• 2-Pyridinecarboxylicacid,3,5-dimethyl-(9CI)
• 3,5-DIBROMO-4-METHOXYPYRIDINE-N-OXIDE
• 3,5-Difluoroisonicotinic acid
• 3,5-Difluoro-4-pyridinecarboxaldehyde
• 2,6-DIBROMO-3,5-DIFLUOROISONICOTINIC ACID
• 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXYLIC ACID, 97
• 2,3,5,6-TETRAFLUOROPYRIDINE-4-CARBOXYLIC ACID
• 2-AMINO-3,5,6-TRIFLUORO-PYRIDINE-4-CARBOXAMIDE
• 2-Amino-3,5,6-trifluoro-4-pyridinecarboxylicacidethylester
• 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXALDEHYDE