OROTIDINE
OROTIDINE Basic information
- Product Name:
- OROTIDINE
- Synonyms:
-
- OROTIDINE
- URIDINE-6-CARBOXYLIC ACID
- URIDIN-6-CARBOXYLIC ACID
- Orotidine (Uridine-6-carboxylic acid)
- 1,2,3,6-Tetrahydro-2,6-dioxo-3-β-D-ribofuranosyl-4-pyrimidinecarboxylic acid
- 6-Carboxyuridine
- 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-2,6-diketo-pyrimidine-4-carboxylic acid
- Orotidine ,98%
- CAS:
- 314-50-1
- MF:
- C10H12N2O8
- MW:
- 288.21
- Mol File:
- 314-50-1.mol
OROTIDINE Chemical Properties
- Melting point:
- >400 °C
- Density
- 1.847±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 2.62±0.20(Predicted)
- color
- White to Off-White
MSDS
- Language:English Provider:SigmaAldrich
OROTIDINE Usage And Synthesis
Uses
Orotidine is a metabolite of Orotic Acid (O691500); a compound used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.
Definition
ChEBI: A nucleoside formed by attaching orotic acid to a ribose ring via a beta1N(1)-glycosidic bond.
Enzyme inhibitor
This water-soluble ribonucleoside (FWfree-acid = 288.21 g/mol; CAS 314-50- 1; lmax of 267 nm in 0.1 N HCl (e = 9570 cm–1M–1; another report lists 9800) and 265 nm in 0.1 N methanolic NaOH (e = 8960 cm–1M–1; another report lists 7800)), first observed in Neurospora crassa, is also foound in the urine of cancer patients treated with 6-azauridine, Orotidine is most likely formed from OMP, its 5’-monophosphate ester and the direct precursor of UMP. Orotidine is readily hydrolyzed in dilute mineral acids. Target(s): orotate phosphoribosyltransferase; orotidine-5’-phosphate decarboxylase.
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OROTIDINE(314-50-1)Related Product Information
- OROTIDINE-5'-MONOPHOSPHATE*PYROPHOSPHORYLASE FROM BR
- Orotidine-5'-Phosphate Decarboxylase
- OROTIDINE-5'-MONOPHOSPHATE*DECARBOXYLASE PURIFIED FR
- orotidine 5'-monophosphate
- OROTIDINE-5'-PHOSPHATE*PYROPHOSPHORYLASE AND OROTID
- OROTIC ACID MONOHYDRATE
- OROTIDINE
- 2-(2-METHYL-THIAZOL-4-YL)-PHENOL
- 6-FORMYL-URACIL MONOHYDRATE
- 6-(HYDROXYMETHYL)URACIL
- N-N-bis(2-hydroxyethyl)formamide
- orotidine 5'-monophosphate trisodium salt,OROTIDINE 5'-MONOPHOSPHATE SODIUM SALT,orotidine 5'-monophosphate trisodium
- acrylic acid, compound with 2-aminoethanol (1:1)