5(S), 15(S)-DIHETE Chemical Properties

storage temp. 

-20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml

form 

Colorless liquid.

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

5(S), 15(S)-DIHETE Usage And Synthesis

Description

5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB₄. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED₅₀ value of 0.3 μM.

Uses

5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.

Uses

5(S),15(S)-DiHETE is an enhancer of neutrophil degranulation and potent chemotaxin.

Definition

ChEBI: 5(S),15(S)-DiHETE is a DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions. It has a role as a rat metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 5(S),15(S)-DiHETE(1-).

5(S), 15(S)-DIHETE(82200-87-1)Related Product Information

• 5(S),15(S)-DIHETE [1-14C]
• 8(S),15(S)-DIHETE [1-14C]
• (8S,15S)-DIHETE
• 8(S),15(S)-DIHETE
• 8(R),15(S)-DIHETE
• 5(S), 15(S)-DIHETE