N-BENZYL-2-CYANOACETAMIDE Chemical Properties

Melting point:

120-122

Boiling point:

425.2±38.0 °C(Predicted)

Density 

1.126±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

6.12±0.10(Predicted)

form 

solid

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2926907090

N-BENZYL-2-CYANOACETAMIDE Usage And Synthesis

Synthesis

GENERAL METHOD: Dissolve sodium ethoxide (0.1 mmol) in ethanol (3 mL), add ethyl cyanoacetate (10 mmol) and benzylamine (10 mmol), and stir the reaction at room temperature. For primary amines, the reaction time was 1 hour; for secondary amines, the reaction time was extended to 2 hours. Upon completion of the reaction, the resulting precipitate was separated by filtration, washed with diethyl ether and recrystallized in ethanol, resulting in N-benzyl-2-cyanoacetamide as a white solid.

References

[1] Organic Letters, 2009, vol. 11, # 9, p. 2003 - 2006
[2] Chemical Communications, 2017, vol. 53, # 12, p. 2020 - 2023
[3] Organic Letters, 2014, vol. 16, # 7, p. 2018 - 2021
[4] Tetrahedron, 2011, vol. 67, # 8, p. 1540 - 1551
[5] Angewandte Chemie - International Edition, 2015, vol. 54, # 9, p. 2849 - 2853

N-BENZYL-2-CYANOACETAMIDE(10412-93-8)Related Product Information

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• 6-(4-CHLOROPHENYL)-1-(3,4-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
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• 1-(4-CHLOROBENZYL)-6-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(4-FLUOROBENZYL)-6-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 3-(4-FLUOROBENZYL)-1-(4-METHOXYPHENYL)-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBONITRILE
• 6-(4-CHLOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-BENZYL-6-(DIMETHOXYMETHYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(3,4-DICHLOROBENZYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(3,4-DICHLOROBENZYL)-6-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(4-CHLOROBENZYL)-6-(DIMETHOXYMETHYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 6-(4-FLUOROPHENYL)-2-OXO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(2,6-DICHLOROBENZYL)-6-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE