2-IMINO-4-METHYLPIPERIDINE ACETATE Chemical Properties

Melting point:

181-182°C

storage temp. 

Store at -20°C

solubility 

DMF: >5 mg/ml; DMSO: >6.5 mg/ml; Ethanol: >23 mg/ml; PBS pH 7.2: >25 mg/ml

form 

A crystalline solid

color 

White to off-white

2-IMINO-4-METHYLPIPERIDINE ACETATE Usage And Synthesis

Description

2-Imino-4-methylpiperidine is a potent, general NOS inhibitor. It exhibits IC₅₀ values of 0.1, 1.1, and 0.2 μM for inhibition of human iNOS, eNOS, and nNOS, respectively, at an arginine concentration of 30 μM.

Uses

2-Imino-4-methylpiperidine is a potent, general NOS inhibitor. It exhibits IC50 values of 0.1, 1.1, and 0.2 μM for inhibition of human iNOS, eNOS, and nNOS, respectively, at an arginine concentration of 30 μM.

Uses

A potent inhibitor of human iNOS (hNOS II).

in vivo

References

[1] R. KEITH WEBBER. Substituted 2-Iminopiperidines as Inhibitors of Human Nitric Oxide Synthase Isoforms?[J]. Journal of Medicinal Chemistry, 1998, 41 1: 96-101. DOI: 10.1021/jm9705059

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