ESTETROL Chemical Properties

Melting point:

233-236°C

Boiling point:

491.9±45.0 °C(Predicted)

Density 

1.343±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO: soluble20mg/mL, clear

pka

10.22±0.70(Predicted)

form 

powder

color 

white to beige

optical activity

[α]/D +125 to +135, c = 1 in ethanol

ESTETROL Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium). In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.

Uses

A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.

Definition

ChEBI: Estetrol is a 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. It has a role as an estrogen, an estrogen receptor agonist, a human metabolite, a human xenobiotic metabolite and an oral contraceptive. It is a 3-hydroxy steroid, a 17beta-hydroxy steroid, a 16alpha-hydroxy steroid, a 15alpha-hydroxy steroid and a steroid hormone. It derives from a hydride of an estrane.

ESTETROL(15183-37-6)Related Product Information

• 1,3,5(10)-ESTRATRIEN-2,3,15-ALPHA, 16-ALPHA, 17-BETA-PENTOL 2-METHYL ETHER
• 1,3,5(10)-ESTRATRIEN-3,15-ALPHA, 16-ALPHA, 17-BETA-TETROL TETRA ACETATE
• Estriol
• 1,3,5(10)-ESTRATRIEN-3,15-ALPHA, 17-BETA-TRIOL
• ESTETROL