1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Chemical Properties

Boiling point:

623.5±55.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at RT

pka

14.13±0.20(Predicted)

1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Usage And Synthesis

Uses

NNC 05-2090 Hydrochloride is a GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters.

Biological Activity

GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (K i values are 1.4, 15, 19 and 41 μ M for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α 1 - and D 2 -receptors (IC 50 values are 266 and 1632 nM respectively).

1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE(184845-43-0)Related Product Information

• 1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE
• 4-(2-METHOXY-PHENYL)-PIPERIDIN-4-OL
• 1-(3-AMINO-PROPYL)-PIPERIDIN-4-OL