S-(P-NITROBENZYL)GLUTATHIONE
S-(P-NITROBENZYL)GLUTATHIONE Basic information
- Product Name:
- S-(P-NITROBENZYL)GLUTATHIONE
- Synonyms:
-
- S-(P-NITROBENZYL)GLUTATHIONE
- (2R)-2-[[(2S)-2-[[2-[[(2S,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)-4-oxanyl]oxy]-1-oxopropyl]amino]-3-methyl-1-oxobutyl]amino]-5-amino-5-oxopentanoic acid
- s-(4-nitrobenzyl)glutathione
- Glycine, L-γ-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl-
- CAS:
- 6803-19-6
- MF:
- C17H22N4O8S
- MW:
- 442.44
- Product Categories:
-
- Glutathione and Derivatives
- Dipeptides and Tripeptides
- Peptides
- Mol File:
- 6803-19-6.mol
S-(P-NITROBENZYL)GLUTATHIONE Chemical Properties
- storage temp.
- 2-8°C
MSDS
- Language:English Provider:SigmaAldrich
S-(P-NITROBENZYL)GLUTATHIONE Usage And Synthesis
Uses
S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system[1][2].
Definition
ChEBI: A glutathione derivative in which the thiol hydrogen of glutathione is replaced by a 4-nitrobenzyl group.
References
[1] I García-Sáez, et al. Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors. J Mol Biol. 1994 Apr 1;237(3):298-314. DOI:10.1006/jmbi.1994.1232
[2] T Suga, et al. Studies on mercapturic acids. Participation of glutathionase in the conversion of glutathione derivatives to cysteine derivatives. J Biochem. 1966 Aug;60(2):133-9. DOI:10.1093/oxfordjournals.jbchem.a128411