(AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE Chemical Properties

storage temp. 

Store at +4°C

solubility 

<50.06mg/ml in DMSO; <25.03mg/ml in ethanol

(AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE Usage And Synthesis

Uses

J 104129 is a mAChR M3 antagonist.

Biological Activity

Potent M 3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M 2 receptors (K i values are 4.2, 19 and 490 nM for human M 3 , M 1 and M 2 receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (K B values are 3.3 and 170 nM for rat trachea M 3 and rat right atria M 2 receptors respectively).

(AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE(244277-89-2)Related Product Information

• (2-CYCLOPENTYL-2-PHENYLETHYL)AMINE
• (AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE