Z-Leu-Leu-Tyr-a-keto aldehyde
Z-Leu-Leu-Tyr-a-keto aldehyde Basic information
- Product Name:
- Z-Leu-Leu-Tyr-a-keto aldehyde
- Synonyms:
-
- Z-Leu-Leu-Tyr-a-keto aldehyde
- L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-[(4-hydroxyphenyl)methyl]-2,3-dioxopropyl]-
- Z-Leu-Leu-Tyr-α-keto aldehyde
- CAS:
- 204649-66-1
- MF:
- C30H39N3O7
- MW:
- 553.65
- Mol File:
- 204649-66-1.mol
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Z-Leu-Leu-Tyr-a-keto aldehyde Chemical Properties
- Boiling point:
- 813.3±65.0 °C(Predicted)
- Density
- 1.188±0.06 g/cm3(Predicted)
- pka
- 9.82±0.15(Predicted)
- Sequence
- {Cbz}-Leu-Leu-Tyr-{COCHO}
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Z-Leu-Leu-Tyr-a-keto aldehyde Usage And Synthesis
Uses
Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a Ki value of 3.0 nM[1].
References
[1] Lynas JF, et, al. Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl alpha-keto aldehydes (glyoxals). Bioorg Med Chem Lett. 1998 Feb 17;8(4):373-8. DOI:10.1016/s0960-894x(98)00030-4
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