5-METHOXYINDOLE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

199-201 °C (lit.)

Boiling point:

326.92°C (rough estimate)

Density 

1.2722 (rough estimate)

refractive index 

1.5310 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

4.38±0.30(Predicted)

form 

Powder

color 

Light yellow to brownish

BRN 

157478

InChIKey

YEBJVSLNUMZXRJ-UHFFFAOYSA-N

CAS DataBase Reference

4382-54-1(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

NL6005000

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-METHOXYINDOLE-2-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

LIGHT YELLOW TO BROWNISH POWDER

Uses

Reactant for preparation of:• ;Anticancer agents1• ;A fluorescent small molecule probe for in vivo lipid imaging2• ;Indoleamine 2,3-dioxygenase (IDO) inhibitors3• ;Selective Dopamine D3 receptor ligands4• ;5-HT4 receptor ligands5• ;Inhibitors of Mycobacterium tuberculosis pantothenate synthetase6• ;Hypoxia selective cytotoxins7• ;Potent antitumor bifunctional DNA alkylating agents8

Uses

5-Methoxyindole-2-carboxylic Acid is a very useful synthetic intermediate. It is a reactant used to prepare anticancer agents, Indoleamine 2,3-dioxygenase (IDO) inhibitors, and potent antitumor bifunctional DNA alkylating agents.

Uses

Reactant for preparation of:

• Anticancer agents
• A fluorescent small molecule probe for in vivo lipid imaging
• Indoleamine 2,3-dioxygenase (IDO) inhibitors
• Selective Dopamine D3 receptor ligands
• 5-HT4 receptor ligands
• Inhibitors of Mycobacterium tuberculosis pantothenate synthetase
• Hypoxia selective cytotoxins
• Potent antitumor bifunctional DNA alkylating agents

Definition

ChEBI: 5-methoxyindole-2-carboxylic acid is an indolecarboxylic acid that is indole-2-carboxylic acid carrying an additional methoxy substituent at position 5. It has a role as a plant metabolite, a hypoglycemic agent and an EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor. It is an indolecarboxylic acid and an aromatic ether.

5-METHOXYINDOLE-2-CARBOXYLIC ACID(4382-54-1)Related Product Information

• 5-METHOXYINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• 5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID
• ETHYL 5,6-DIMETHOXYINDOLE-2-CARBOXYLATE
• Alpertine
• ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
• ETHYL 5-(TRIFLUOROMETHOXY)INDOLE-2-CARBOXYLATE
• 5-METHOXYINDOLE-2-CARBOXYLIC ACID
• 3-IODO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 7-METHOXYINDOLE-3-CARBOXYLIC ACID
• 4-METHOXYINDOLE-3-CARBOXYLIC ACID
• 6-METHOXYINDOLE-3-CARBOXYLIC ACID
• 3-HYDROXYMETHYL-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 5-METHOXYINDOLE-3-CARBOXYLIC ACID
• 4-METHOXYINDOLE-2-CARBOXYLIC ACID METHYL ESTER
• 6-METHOXYINDOLE-2-CARBOXYLIC ACID
• 4-METHOXYINDOLE-2-CARBOXYLIC ACID
• 3-FORMYL-6-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 6-amino-5-methoxyindole-2-carboxylic acid ethyl ester