2-Bromo-5-ethynylpyridine Chemical Properties

Melting point:

83℃

Boiling point:

231.0±25.0 °C(Predicted)

Density 

1.60±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-0.73±0.10(Predicted)

InChI

InChI=1S/C7H4BrN/c1-2-6-3-4-7(8)9-5-6/h1,3-5H

InChIKey

WRORYOXBXUUDJL-UHFFFAOYSA-N

SMILES

C1(Br)=NC=C(C#C)C=C1

2-Bromo-5-ethynylpyridine Usage And Synthesis

Uses

2-Bromo-5-ethynylpyridine is used in the synthesis of macrocycle of terpyridine units.

Preparation

The iodobromopyridine (2-Bromo-5-iodopyridine), the starting material, was coupled with TMS-acetylene under Sonogashira conditions. One-pot deprotection and recrystallization could yield the bromo,ethynyl-functionalized pyridine (2-Bromo-5-ethynylpyridine)[1].

Reactions

2-Bromo-5-ethynylpyridine is a useful organic compound that could be used to synthesize 2-Bromo-5-[(3-iodophenyl)ethynyl]pyridine, 2-bromo-5-({4-[(tert-butyldimethylsilyl)oxy]phenyl}ethynyl)pyridine, and so on.