N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Basic information
- Product Name:
- N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
- Synonyms:
-
- TMP-195;TMP195;TMP 195
- CS-2651
- TFMO 2
- N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide
- TMP 195
- TMP 195 - TFMO 2
- TMP195; TMP-195
- Inhibitor,TMP195,TMP-195,HDAC,Histone deacetylases,inhibit
- CAS:
- 1314891-22-9
- MF:
- C23H19F3N4O3
- MW:
- 456.42
- Product Categories:
-
- API
- Mol File:
- 1314891-22-9.mol
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N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Chemical Properties
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.2 mg/ml
- form
- A crystalline solid
- pka
- 13.05±0.46(Predicted)
- color
- White to off-white
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N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Usage And Synthesis
Biological Activity
TMP195 (TFMO 2) is a selective class IIa HDAC inhibitor with IC50 of 300 nM in cell-based assays.
in vitro
TMP195 has low potency in recombinant class I and class IIb HDAC assays, and is able to completely inhibit class IIa HDAC activity without inhibiting other HDACs. In the supernatant of monocyte-derived macrophage differentiation medium, it prevented the accumulation of CCL2 protein; compared with the control group, it could significantly increase the level of CCL1 protein secreted by monocytes.
target
| Target | Value |
| HDAC9 (Cell-free assay) | 15 nM(Ki) |
| HDAC7 (Cell-free assay) | 26 nM(Ki) |
| HDAC4 (Cell-free assay) | 59 nM(Ki) |
| HDAC5 (Cell-free assay) | 60 nM(Ki) |
N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMideSupplier
ShangHai YuanYe Biotechnology Co., Ltd.
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MedChemexpress LLC
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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AdooQ Bioscience CHINA
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