Azido-PEG3-PFP ester
Azido-PEG3-PFP ester Basic information
- Product Name:
- Azido-PEG3-PFP ester
- Synonyms:
-
- perfluorophenyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
- N3-PEG3-C2-PFP ester
- Azido-PEG3-PFP ester
- N3-PEG3-PFP
- N3-PEG3-PFP ESTER
- Azido-PEG3-PFP
- N3-PEG3-CH2CH2COOPFP
- N3-PEG3-OPFP
- CAS:
- 1807530-07-9
- MF:
- C15H16F5N3O5
- MW:
- 413.3
- Product Categories:
-
- peg
- Mol File:
- 1807530-07-9.mol
Azido-PEG3-PFP ester Chemical Properties
- solubility
- Soluble in DMSO, DCM, DMF
Azido-PEG3-PFP ester Usage And Synthesis
Description
Azido-PEG3-PFP ester is a PEG reagent consistig of an azide and PFP ester moities. The azide is reactive with copper-catalyzed Click Chemistry reactions with propargyl, copper-free click chemistry with DBCO and BCN. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.
Uses
N3-PEG3-C2-PFP ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-C2-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Non-cleavable Linker
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