ANTI-AMYLOID, BETA Chemical Properties

storage temp. 

−20°C

solubility 

DMSO: ≥50mg/mL

form 

buffered aqueous solution

color 

white to off-white

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

MSDS

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ANTI-AMYLOID, BETA Usage And Synthesis

Uses

The antibody is useful in immunohistochemistry, immunoblotting, ELISA, and competitive ELISA. Also, this antibody has been used to neutralize Aβ assemblies in brains of transgenic mice expressing a mutant form of amyloid precursor protein, and for in vivo deep tissue imaging using near-IR optical spectrum.

General Description

The antibody reacts specifically with β-amyloid protein. The epitope recognized by the antibody resides within amino acids 1-12 of the β-amyloid protein. It specifically stains amyloid plaques within the cortex and amyloid deposits in blood vessels using formic acid-treated, formalin-fixed, paraffin-embedded, and Methacarn-fixed sections of human Alzheimer′s disease (AD) brain tissue.

Biochem/physiol Actions

β-amyloid gene acts as the substrate of insulin-degrading enzyme (IDE). It plays a major role in the pathogenesis of Alzheimer′s disease (AD) and type 2 diabetes mellitus (DM2).