Super-TDU Chemical Properties

storage temp. 

Store at -20°C

form 

Solid

color 

White to off-white

Sequence

Ser-Val-Asp-Asp-His-Phe-Ala-Lys-Ser-Leu-Gly-Asp-Thr-Trp-Leu-Gln-Ile-Gly-Gly-Ser-Gly-Asn-Pro-Lys-Thr-Ala-Asn-Val-Pro-Gln-Thr-Val-Pro-Met-Arg-Leu-Arg-Lys-Leu-Pro-Asp-Ser-Phe-Phe-Lys-Pro-Pro-Glu

Super-TDU Usage And Synthesis

Uses

Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model[1].

Biological Activity

Super-TDU is an inhibitory polypeptide targeting YAP-TEADs interaction.

in vivo

Super-TDU can treat gastric cancer by directly targeting YAP-TEADs, unlike the traditional drug compound 5-FU, whose antitumor activity tends to be more towards tumors with a high ratio of YAP/VGLL4.

target

IC 50

YAP/TAZ-TEAD

References

[1] Jiao S, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014 Feb 10;25(2):166-80. DOI:10.1016/j.ccr.2014.01.010

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