Ethanone, 1-[4-(4-chloro-3-methoxyphenyl)-1-piperazinyl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]- Chemical Properties

Boiling point:

778.4±60.0 °C(Predicted)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

11.27±0.10(Predicted)

color 

Off-white to light yellow

Ethanone, 1-[4-(4-chloro-3-methoxyphenyl)-1-piperazinyl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]- Usage And Synthesis

Uses

CCX354 is an antagonist of CCR1, with anti-inflammatory activity.

in vivo

IC 50

CCR1

References

[1] Compounds for the treatment of osteoporosis and cancers. US 20100113472 A1