msx-130
msx-130 Basic information
- Product Name:
- msx-130
- Synonyms:
-
- msx-130
- MSX-130; MSX 130; MSX130
- 1H-Imidazole, 2,2'-(1,4-phenylene)bis[4,5-diphenyl-
- 1,4-bis(4,5-diphenyl-1H-imidazol-2-yl)benzene
- CXCR4,MSX130,metastasis,Inhibitor,antagonist,CXC chemokine receptors,CXCR,MSX-130,cancer,inhibit
- 2-[4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)PHENYL]-4,5-DIPHENYL-1H-IMIDAZOLE
- MSX-130 ，S0293
- CAS:
- 4051-59-6
- MF:
- C36H26N4
- MW:
- 514.62
- Mol File:
- 4051-59-6.mol
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msx-130 Chemical Properties
- solubility
- DMSO:3.0(Max Conc. mg/mL);5.83(Max Conc. mM)
- form
- A solid
- color
- Light yellow to green yellow
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msx-130 Usage And Synthesis
Uses
MSX-130 is a CXCR4 antagonist. MSX-130 inhibits cancer metastasis[1].
Biological Activity
MSX-130 is a CXCR4 antagonist. It inhibits tumor metastasis.
in vitro
The CXC chemokine receptor-4 (CXCR4) is a seven trans-membrane G-protein coupled receptor (GPCR) classified as a member of the family I GPCR or rhodopsin-like GPCR family. CXCR4 plays an important role in cancer metastasis, regulation of stem cell trafficking, and neovascularization.
target
| CXCR4
|
IC 50
CXCR4
References
[1] Zhan W, et al. Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50(23):5655-64. DOI:10.1021/jm070679i
msx-130Supplier
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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- 0431-0431-80514535 19917294565
- et@chemextension.com
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
- 3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
- klq@cw-bio.com
Shanghai SuperLan Chemcial Technique Centre
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- 0-2022843681 15618226720
- chaolaichem@foxmail.com