N-(Propargyl-PEG4)-Biocytin Chemical Properties

Boiling point:

916.2±65.0 °C(Predicted)

Density 

1.202±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DMF

pka

3.54±0.10(Predicted)

form 

Solid

color 

Light yellow to light brown

N-(Propargyl-PEG4)-Biocytin Usage And Synthesis

Description

N-(Propargyl-PEG4)-biocytin is a biotin PEG reagent that is reactive with azide containing molecule via click chemistry.

Uses

N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG4)-biocytin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005