ARS-1620
ARS-1620 Basic information
- Product Name:
- ARS-1620
- Synonyms:
-
- ARS-1620
- CPD1588
- ARS-1620;ARS 1620;ARS1620
- (S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
- 1-?[4-?[(7S)?-?6-?Chloro-?8-?fluoro-?7-?(2-?fluoro-?6-?hydroxyphenyl)?-?4-?quinazolinyl]?-?1-?piperazinyl]?-?2-?propen-?1-?one
- 2-Propen-1-one, 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-
- (S)-1-[4-[6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one
- inhibit,Ras,Inhibitor,ARS-1620,ARS 1620,ARS1620
- CAS:
- 1698055-85-4
- MF:
- C21H17ClF2N4O2
- MW:
- 430.84
- Product Categories:
-
- APIs
- API
- Mol File:
- 1698055-85-4.mol
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ARS-1620 Chemical Properties
- Boiling point:
- 614.7±55.0 °C(Predicted)
- Density
- 1.434±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:70.0(Max Conc. mg/mL);162.47(Max Conc. mM)
- form
- A solid
- pka
- 6.03±0.35(Predicted)
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ARS-1620 Usage And Synthesis
Uses
ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
Definition
ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.
ARS-1620Supplier
ShangHai ChuanQian Chemcial Technique Centre Gold
- Tel
- 15869524721
- 3525679403@qq.com
Twochem Co.Ltd Gold
- Tel
- 021-58111628 15800915896
- sales@twochem.com
ShangHai Caerulum Pharma Discovery Co., Ltd. Gold
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Energy Chemical
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com