COLLISMYCIN A Chemical Properties

Melting point:

173-174 °C

Boiling point:

450.7±45.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble

form 

A solid

pka

9.75±0.50(Predicted)

COLLISMYCIN A Usage And Synthesis

Uses

Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was discovered as a potent inhibitor of glucocorticoid receptor binding. Collismycin has weak to moderate activity against bacteria, fungi and tumor cell lines. More recently, collismycin has been found to be a potent and selective neuroprotective agent against oxidative stress. Other recent publications have focused on the biosynthesis of collismycin as a route to the production of related analogues.

Uses

Collismycin A is a microbial product that exhibits anti-proliferative activity against cancer cells. Collismycin A is also an iron chelator and used to develop neuroprotective compounds.

COLLISMYCIN A(158792-24-6)Related Product Information

• 6-METHYL-2,2'-BIPYRIDINE
• 4-Hydroxy-2,6-dimethylpyridine
• 6-methylpyridine-2-carbaldehyde oxime
• 4-METHOXY-2,6-DIMETHYLPYRIDINE
• CAERULOMYCIN A
• COLLISMYCIN A