(+/-)11-HETE Chemical Properties

storage temp. 

Store at -20°C

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

(+/-)11-HETE Usage And Synthesis

Description

(±)11-HETE is an oxylipin formed non-enzymatically from arachidonic acid .^1,2 Levels of (±)11-HETE are increased in an in vitro model of lipid peroxidation induced by ferrous ammonium sulfate (FAS) in rat brain homogenates.³ Levels are also increased in rat liver in an in vivo model of lipid peroxidation induced by carbon tetrachloride (CCl₄). It has been found in skin extracts from individuals with psoriasis and in atherosclerotic plaques.^4,5

Uses

11-HETE (11-Hydroxy-5,8,12,14-eicosatetraenoic acid) is the activator for cytochrome P450. 11-HETE upregulates the mRNA expressions of CYP1B1, CYP1A1, CYP4A11, CYP4F11, and CYP4F2, induces cell hypertrophy in RL-14 cell, and exhibits potential to be used in cardiovascular diseases[1].

References

1. Powell, W.S., and Rokach, J. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid Biochim. Biophys. Acta 1851(4),340-355(2014).
2. Derogis, P.B.M.C., Chaves-Filho, A.B., and Miyamoto, S. Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometry Bioactive lipids in health and disease ,21-38(2019).
3. Guido, D.M., McKenna, R., and Mathews, W.R. Quantitation of hydroperoxy-eicosatetraenoic acids and hydroxy-eicosatetraenoic acids as indicators of lipid peroxidation using gas chromatography-mass spectrometry Anal. Biochem. 209(1),123-129(1993).
4. Camp, R.D.R., Mallet, A.I., Woollard, P.M., et al. The identification of hydroxy fatty acids in psoriatic skin Prostaglandins 26(3),431-447(1983).
5. Waddington, E., Sienuarine, K., Puddey, I., et al. Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography Anal. Biochem. 292(2),234-244(2001).

(+/-)11-HETE(73804-65-6)Related Product Information

• (Z,Z)-3,6-NONADIEN-1-OL
• 1.3.7-OCTATRIENE
• 11(R)-HETE
• (+/-)11-HETE
• 11(S)-HETE