AB-423
AB-423 Basic information
- Product Name:
- AB-423
- Synonyms:
-
- AB-423
- CS-2686
- AB423;AB-423;AB 423
- Benzamide, N-(3,4-difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]-
- N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide
- AB 423,HBV,AB423,inhibit,Hepatitis B virus,AB-423,Inhibitor
- AB-423, 10 mM in DMSO
- AB-423 (AB423
- CAS:
- 1572510-80-5
- MF:
- C17H17F3N2O3S
- MW:
- 386.39
- Mol File:
- 1572510-80-5.mol
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AB-423 Chemical Properties
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:88.5(Max Conc. mg/mL);229.04(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);199.28(Max Conc. mM) - form
- Solid
- pka
- 10.84±0.70(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 1572510-80-5
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AB-423 Usage And Synthesis
Uses
N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide, is an inhibitor of HBV capsid assembly. AB-423 shows inhibitory effect on rcDNA production in AML12-HBV10 and HepDE19 cells with EC50s of ～0.260 μM
in vivo
AB-423 (30 and 100 mg/kg, p.o. bid) blocks HBV replication in a mouse model of HBV. AB-423 (100 mg/kg, p.o. bid) with entecavir (ETV, 100 ng/mg, qd, p.o.) or 0.1 mg/kg dose of ARB-1467 potently inhibits serum HBV DNA in an HDI model of HBV in immunodeficient NOD-SCID mice[1].
AB-423Supplier
BOC Sciences
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- 1-631-485-4226; 16314854226
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Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
BOC Sciences
- Tel
- 16314854226
- info@bocsci.com
ShangHai Angti Biotechnology Co., Ltd.
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- 13764913901
- info@angtibio.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com