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6-methylpurine riboside

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6-methylpurine riboside Basic information

Product Name:
6-methylpurine riboside
Synonyms:
  • 6-METHYLPURINE RIBOSIDE
  • 6-Methyl-9.beta.-D-ribofuranosylpurine
  • 6-Methylpurine ribonucleoside
  • 9H-Purine, 6-methyl-9-.beta.-D-ribofuranosyl-
  • Nsc101619
  • 6-D-MPR
  • 6-Methylpurine-beta-D-riboside
  • 6-Methylpurine-9-beta-D-ribofuranoside
CAS:
14675-48-0
MF:
C11H14N4O4
MW:
266.25
Mol File:
14675-48-0.mol
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6-methylpurine riboside Chemical Properties

Melting point:
209-210 °C
Boiling point:
590.4±60.0 °C(Predicted)
Density 
1.81±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
13.13±0.70(Predicted)
InChI
InChI=1/C11H14N4O4/c1-5-7-10(13-3-12-5)15(4-14-7)11-9(18)8(17)6(2-16)19-11/h3-4,6,8-9,11,16-18H,2H2,1H3/t6-,8-,9-,11-/s3
InChIKey
FIGBCBGMUIGJBD-SOMIAQKHNA-N
SMILES
N1(C=NC2C(C)=NC=NC1=2)[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 |&1:10,11,13,15,r|
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
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6-methylpurine riboside Usage And Synthesis

Description

6-Methylpurine-β-D-riboside (β-D-MPR; 6-methylpurine riboside), an antibiotic isolated from culture broths of the basidiomycetes fungi Collybia dryophilia and Collybia maculata, has antifungal, antiviral and antitumor activity. β-D-MPR is an excellent substrate of mammalian adenosine deaminase (ADA), and its mechanism of activation in tumor cells presumably relates to its interaction with this enzyme [1].

References

[1] Sufrin, J . "Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers." Molecules 10(2005).

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