Basic information Safety Supplier Related

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE

Basic information Safety Supplier Related

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Basic information

Product Name:
6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE
Synonyms:
  • OLOMOUCINE, ISO-
  • ISO-OLOMOUCINE
  • Ethanol, 2-[[7-Methyl-6-[(phenylMethyl)aMino]-7H-purin-2-yl]aMino]-
  • 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE
CAS:
101622-50-8
MF:
C15H18N6O
MW:
298.34
Mol File:
101622-50-8.mol
More
Less

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Chemical Properties

Density 
1.36
storage temp. 
Store at -20°C
solubility 
≤0.3mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
form 
Off-white solid.
More
Less

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Usage And Synthesis

Uses

Iso-olomoucine is a potent and selective inhibitor of cdc2, cdk and orther cyclin related kinases.

Definition

ChEBI: 2-[[7-methyl-6-[(phenylmethyl)amino]-2-purinyl]amino]ethanol is a thiopurine.

Biological Activity

iso-olomoucine is an inactive stereoisomer of the cdk5 inhibitor olomoucine.cyclin-dependent kinases (cdks) are reported to be key regulators of cell cycle progression whose function/dysfunction has been implicated in cancer, human neurodegenerative diseases, as well as the response of addictive drugs through alteration of postsynaptic dopamine receptor signaling.

in vitro

in a previous study, rat dorsal striatal synaptosomes were incubation with the cdk5 inhibitors roscovitine, olomoucine, and gw8510 or the inactive congener iso-olomoucine, which led to a rapid, concentration-dependent inhibition of specific [3h]da uptake. however, roscovitine was the only inhibitor that did not decrease [3h]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding to dstr dats. roscovitine-induced inhibition of dstr [3h]da uptake was demonstrated by decreased maximal uptake velocity, without a change in cell-surface dat levels. moreover, roscovitine did not enhance [3h]da release mediated by either dat reverse-transport. instead, roscovitine could enhance spontaneous [3h]da outflow and inhibit dat-mediated [3h]da reaccumulation into dstr slices. additionally, in a cdk5-independent manner, iso-olomoucine was able to rapidly inhibit dopamine transporter activity in rat dorsal striatal synaptosomes with a potency similar to that of olomoucine (ic50 ~37 μm) [1]

IC 50

≥ 1 mm for cdk5

References

[1] price, d. a.,sorkin, a. and zahniser, n.r. cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. molecular pharmacology 76(4), 812-823 (2009).

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINESupplier

Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Email
info@sagechem.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Alfa Chemistry
Tel
Email
Info@alfa-chemistry.com
BOC Sciences
Tel
Email
info@bocsci.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Email
sales@chemegen.com