Basic information Safety Supplier Related

PAI-1

Basic information Safety Supplier Related

PAI-1 Basic information

Product Name:
PAI-1
Synonyms:
  • ARMAPE
  • MOUSE PAI-1
  • MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1
  • PAI-1
  • PAI-1, HUMAN
  • PAI-1, MOUSE
  • PAI-1, MUTANT, MOUSE
  • PAI-1, RAT
MF:
C27H47N9O9S
MW:
673.78
Product Categories:
  • enzyme
Mol File:
Mol File
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PAI-1 Usage And Synthesis

Enzyme inhibitor

This 402-residue serine protease inhibitor, or serpin (MW = 45074 g/mol; Abbreviation: PAI-1) binds to and inhibits plasminogen activators-tissuetype plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). This inhibition reduces plasmin production and suppresses dissolution of fibrin clots. Elevated PAI-1 levels correlate with an increased cardiovascular disease risk, a behavior that has also been linked to obesity and metabolic syndrome. Pharmacological suppression of PAI-1 is a likely way to prevent or treat vascular disease. Reduced PAI-1 levels may result in increased fibrinolysis and an associated bleeding diathesis. PAI-1 was initially identified in the 1980s, and the first reported case of PAI-1 deficiency appeared in 1989. Unambiguous proof that PAI-1 deficiency as a cause of a bleeding disorder has been rare, but use of selective PAI inhibitors (See PAI-749) may clarify this point. Because of lack of standardized commercially available PAI-1 activity assay sensitive in the lowest range, the true prevalence of this rare condition has yet to be established.

PAI-1Supplier

Shanghai Yaji Biological Technology Co., Ltd.
Tel
021-34661275 15301693058
Email
yajikit@163.com
Shanghai Huzhen Industrial Co., LTD
Tel
021-60345367 13916550749
Email
sales@shzbio.com
United States Biological
Tel
1-800-520-3011
Email
sales@advtechind.com