5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

206-208 °C (decomp)

Boiling point:

452.3±33.0 °C(Predicted)

Density 

1.285±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

4.45±0.10(Predicted)

Appearance

Off-white to pale purple Solid

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

HazardClass 

IRRITANT

5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Usage And Synthesis

Synthesis

5-Phenylpyrrole-2-carboxylate (20 mg, 0.09 mmol) was dissolved in a solvent mixture of 1 mL of tetrahydrofuran, 0.5 mL of methanol and 0.5 mL of water. After stirring at room temperature, LiOH (4 mg, 0.18 mmol) was added. Stirring was continued at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming that the reaction was complete, the solvent was removed using a rotary evaporator. Ice water was added to the reaction residue, which was then acidified with 1 M HCl solution to the appropriate pH and the precipitate was collected by filtration to afford 5-phenyl-1H-pyrrole-2-carboxylic acid (10 mg, 59% yield).

References

[1] Patent: CN107151255, 2017, A. Location in patent: Paragraph 0244; 0245; 0246
[2] Magnetic Resonance in Chemistry, 2009, vol. 47, # 12, p. 1101 - 1109

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