4-PHENYL-3-BUTYN-2-ONE Chemical Properties

Melting point:

4°C

Boiling point:

75-76 °C/0.8 mmHg (lit.)

Density 

0.99 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.574(lit.)

Flash point:

203 °F

storage temp. 

2-8°C

form 

clear liquid

Specific Gravity

1.02

color 

Colorless to Yellow to Green

Water Solubility 

Insoluble in water.

CAS DataBase Reference

1817-57-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-27-37/39

RIDADR 

UN 3334

WGK Germany 

3

RTECS 

ES0890000

HS Code 

2914390090

Toxicity

mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05642,

MSDS

• Language:English Provider:SigmaAldrich

4-PHENYL-3-BUTYN-2-ONE Usage And Synthesis

Uses

It is used as pharmaceutical intermediate.

Definition

ChEBI: 4-phenylbut-3-yn-2-one is a ynone.

Synthesis Reference(s)

Chemistry Letters, 9, p. 1327, 1980
The Journal of Organic Chemistry, 47, p. 2549, 1982 DOI: 10.1021/jo00134a010
Tetrahedron Letters, 29, p. 2321, 1988 DOI: 10.1016/S0040-4039(00)86048-7

General Description

4-Phenyl-3-butyn-2-one is an α,β-ketoalkyne. Reaction of 4-phenyl-3-butyn-2-one with bromine chloride and iodine monochloride in CH₂Cl₂, CH₂Cl₂/pyridine and MeOH are studied. Reduction of 4-phenyl-3-butyn-2-one in THF solution has been reported.

4-PHENYL-3-BUTYN-2-ONE(1817-57-8)Related Product Information

• 3-Butyn-2-one
• 1-(1-Naphthalenyl)-4-phenyl-1-butyn-3-one
• 1-(1-Naphthalenyl)-4-phenyl-3-butyn-2-one
• 1-Phenyl-2-butyn-1-one
• 4-Chloro-4,4-difluoro-1-phenyl-1-butyn-3-one
• 4-PHENYL-3-BUTYN-2-ONE
• 1-(4-NITRO-PHENYL)-3-PHENYL-PROPYNONE
• 1-(4-METHOXY-PHENYL)-3-PHENYL-PROPYNONE
• 1-NAPHTHALEN-1-YL-3-PHENYL-PROPYNONE
• 3-(3,4-DIMETHOXY-PHENYL)-1-P-TOLYL-PROPYNONE
• 4-METHYL-1-PHENYL-PENT-1-YN-3-ONE
• 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE
• DIPHENYLPROPYNONE
• 3-PHENYL-1-P-TOLYL-PROPYNONE
• 3-(4-METHOXY-PHENYL)-1-(4-METHYLPHENYL)-PROPYNONE