5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Chemical Properties

Melting point:

177-180°C

Boiling point:

298.2±50.0 °C(Predicted)

Density 

1.569±0.06 g/cm3(Predicted)

Flash point:

5℃

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: soluble20mg/mL, clear

pka

3.59±0.10(Predicted)

form 

powder

color 

white to beige

CAS DataBase Reference

175205-09-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25-36/37/38

Safety Statements 

26-45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

Hazard Note 

Irritant

5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Usage And Synthesis

Uses

KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].

References

[1] Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. DOI:10.1021/cb300604u
[2] Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. DOI:10.17219/acem/68979

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