HS1371
HS1371 Basic information
- Product Name:
- HS1371
- Synonyms:
-
- HS1371
- CS-2831
- HS-1371; HS 1371; HS1371;2158197-70-5
- Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
- HS-1371,Inhibitor,Receptor-interacting protein kinases,RIPK,inhibit,HS 1371,RIP kinase,HS1371
- 7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline
- HS-1371, 10 mM in DMSO
- CAS:
- 2158197-70-5
- MF:
- C24H24N4O
- MW:
- 384.47
- Product Categories:
-
- API
- Mol File:
- 2158197-70-5.mol
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HS1371 Chemical Properties
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMF:30.0(Max Conc. mg/mL);78.03(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.52(Max Conc. mM)
DMSO:11.56(Max Conc. mg/mL);30.06(Max Conc. mM)
Ethanol:4.5(Max Conc. mg/mL);11.7(Max Conc. mM) - form
- A solid
- color
- White to off-white
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HS1371 Usage And Synthesis
Biological Activity
HS1371 is a potent RIP3 kinase inhibitor with IC50 of 20.8 nM. It binds to the ATP-binding region of RIP3, thereby preventing ATP binding, inhibiting the enzymatic activity of RIP3 in vitro.
in vitro
HS1371 inhibits autorenal phosphorylation of RIP3 at S227. In HT-29 cells, it has full inhibitory activity on TNF-induced necroptosis signaling and is inactive on the phosphorylation of RIP3 and MLKL. It protects cells from RIP3-dependent necrotic cell death but does not affect apoptotic cell death.
target
| Target | Value |
| RIP3 kinase () | 20.8 nM |
HS1371Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
Tianjin Kailiqi Biotechnology Co., Ltd.
- Tel
- 15076683720
- klq@cw-bio.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 17754423994 17754423994
- 2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
- Tel
- 21-31433387 15618786686
- sales@rechemscience.com