(S)-PBMC (PBMC)
(S)-PBMC (PBMC) Basic information
- Product Name:
- (S)-PBMC (PBMC)
- Synonyms:
-
- (S)-PBMC (PBMC)
- Carbamic acid, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, (1S)-1-phenylethyl ester
- CAS:
- 1352138-54-5
- MF:
- C26H30N2O4
- MW:
- 434.53
- Mol File:
- 1352138-54-5.mol
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(S)-PBMC (PBMC) Chemical Properties
- Boiling point:
- 584.6±50.0 °C(Predicted)
- Density
- 1.165±0.06 g/cm3(Predicted)
- storage temp.
- -20°C (des.)
- solubility
- Soluble in DMSO (up to 30 mg/ml).
- pka
- 9.17±0.10(Predicted)
- form
- oil
- color
- Light brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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(S)-PBMC (PBMC) Usage And Synthesis
Description
PBMC (1352138-54-5) is a potent and selective blocker of TRPM8 channels. PBMC blocks both chemical and thermal activation of TRPM8.1?Reverses the menthol and cold-induced facilitation of the micturition reflex.2?PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3
References
1) Knowlton et al. (2011), Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice; PLoS One, 6(9) e25894 2) Gardiner et al. (2014), The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist; Eur. J. Pharmacol., 740 398 3) Salat et al. (2013), Transient receptor potential channels – emerging novel drug targets for the treatment of pain; Curr. Med. Chem., 20 1409