(S)-PBMC (PBMC)
(S)-PBMC (PBMC) Basic information
- Product Name:
- (S)-PBMC (PBMC)
- Synonyms:
-
- (S)-PBMC (PBMC)
- Carbamic acid, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, (1S)-1-phenylethyl ester
- N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-carbamic acid (1S)-1-phenylethyl ester
- CAS:
- 1352138-54-5
- MF:
- C26H30N2O4
- MW:
- 434.53
- Mol File:
- 1352138-54-5.mol
(S)-PBMC (PBMC) Chemical Properties
- Boiling point:
- 584.6±50.0 °C(Predicted)
- Density
- 1.165±0.06 g/cm3(Predicted)
- storage temp.
- -20°C (des.)
- solubility
- Soluble in DMSO (up to 30 mg/ml).
- pka
- 9.17±0.10(Predicted)
- form
- oil
- color
- Light brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
(S)-PBMC (PBMC) Usage And Synthesis
Description
PBMC (1352138-54-5) is a potent and selective blocker of TRPM8 channels. PBMC blocks both chemical and thermal activation of TRPM8.1?Reverses the menthol and cold-induced facilitation of the micturition reflex.2?PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3
References
[1] WENDY M KNOWLTON. Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice.[J]. PLoS ONE, 2011: e25894. DOI:10.1371/journal.pone.0025894
[2] JENNIFER C. GARDINER . The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist[J]. European journal of pharmacology, 2014, 740: Pages 398-409. DOI:10.1016/j.ejphar.2014.07.022
[3] KINGA SAŁAT Tadeusz L Andrzej Moniczewski. Transient receptor potential channels - emerging novel drug targets for the treatment of pain.[J]. Current medicinal chemistry, 2013, 20 11: 1409-1436. DOI:10.2174/09298673113209990107