BAY 61-3606
BAY 61-3606 Basic information
- Product Name:
- BAY 61-3606
- Synonyms:
-
- BAY 61-3606 free base
- CS-2745
- Syk Inhibitor IV, BAY 61-3606: sc-202351 hydrochloride
- Syk Inhibitor IV, BAY 61-3606 HCl
- BAY 61-3606
- BAY 61-3606 hydrate hydrochloride
- 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide
- BAY-61-360
- CAS:
- 732983-37-8
- MF:
- C20H18N6O3
- MW:
- 390.4
- Mol File:
- 732983-37-8.mol
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BAY 61-3606 Chemical Properties
- Density
- 1.41
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- solid
- color
- yellow
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BAY 61-3606 Usage And Synthesis
Uses
Syk Inhibitor IV is an imidazopyrimidine inhibitor of Syk and Syk-mediated functions.
Definition
ChEBI: 2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide is a member of pyrimidines.
Biological Activity
Cell permeable: yes', 'Primary Target
Syk', 'Product competes with ATP.', 'Reversible: yes
in vivo
Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor[4].
| Animal Model: | Female BALB/c nude mice (5 weeks old) bearing MCF-7 tumor xenograft[4] |
| Dosage: | 50 mg/kg |
| Administration: | Injected intraperitoneally twice a week with Bay 61-3606 (50 mg/kg), TRAIL (10 mg/kg) or a combination of Bay 61-3606 (50 mg/kg) and TRAIL (10 mg/kg); TRAIL was given 2 h after the injection of Bay 61-3606; for two weeks |
| Result: | Led to efficacious reductions in tumor growth. |
BAY 61-3606Supplier
Chembest Research Laboratories Limited
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- +86-21-20908456
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BOC Sciences
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- 1-631-485-4226; 16314854226
- info@bocsci.com
MedChemexpress LLC
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- 021-58955995
- sales@medchemexpress.cn
AdooQ BioScience, LLC
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- +1 (866) 930-6790
- info@adooq.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com