1，1-DIMETHYLBIGUANIDE HYDROCHLORIDE Chemical Properties

Melting point:

223-226 °C(lit.)

InChI

InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChIKey

OETHQSJEHLVLGH-UHFFFAOYSA-N

SMILES

N(C)(C)C(NC(N)=N)=N.[H]Cl

CAS DataBase Reference

15537-72-1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

DU1800000

1，1-DIMETHYLBIGUANIDE HYDROCHLORIDE Usage And Synthesis

Uses

Metformin hydrochloride can be used for the following purposes: 1. Type 2 diabetic patients whose condition is not adequately controlled by diet alone (for obese patients and those with hyperinsulinemia, this drug not only lowers blood sugar but also helps reduce weight and alleviate hyperinsulinemia); 2. Certain diabetic patients who respond poorly to sulfonylureas (it can be used in combination with sulfonylureas).

Originator

Diabetex ,Germania

Definition

ChEBI: Metformin hydrochloride is a hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride. It has a role as an environmental contaminant, a hypoglycemic agent and a xenobiotic. It contains a metformin(1+).

Manufacturing Process

The boiling mixture of 1,000 L xylene, 450 kg dimethylamine and 840 kg dicyanamide was added 365 kg hydrogene chloride. Yield of biguanide, 1,1- dimethyl-, hydrochloride 1,588 kg (96%). Biguanide, 1,1-dimethyl-, hydrochloride may be recrystallysed from methanol.

Therapeutic Function

Oral hypoglycemic